Keratins

A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.

Also Known As:

Keratin; Cytokeratin; Keratin-Associated Proteins; alpha-Keratin; Associated Protein, Keratin; Keratin Associated Proteins; Protein, Keratin Associated; alpha Keratin; Keratin Associated Protein

Macromolecular Substances: 97
- Polymers: 13529
  - Biopolymers: 836
    - Intermediate Filament Proteins: 287
      - Keratins: 10504
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Cytoskeletal Proteins: 743
    - Intermediate Filament Proteins: 287
      - Keratins: 10504
  - Scleroproteins: 75
    - Keratins: 10504

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Disease

Drug/Important Bio-Agent (IBA)